Relationship between protein and structure

Indicate the statements that support the relationship between protein and structure

 1.)A protein that unfolds or is incorrectly folded can use chaperones to correct the structure

2.) when some proteins are denatured, with return of the normal environmental conditions they might refold

3.) A protein’s final shape is determined by the secondary structure 

4.) pH, temp and agitation can denature proteins rendering them active 

5. ) A disease may occur if proteins don’t fold correctly Based on the reading I chose 2 & 4, did I miss something. If so please explain

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